English Premier League side have announced they have terminated the contract of their Head Coach, Nuno Espirito Santo, following their 3-0 defeat against Manchester United.
The departure of Nuno, who left Wolves in May after four seasons in charge, means Tottenham are looking for their fourth permanent manager in the last three years.
A Spurs statement said: “The club can today announce that Nuno Espírito Santo and his coaching staff Ian Cathro, Rui Barbosa and Antonio Dias have been relieved of their duties.
“A further coaching update will follow in due course.”
Tottenham are eighth in the Premier League, 10 points off leaders Chelsea. Their next action is at home game against Vitesse Arnhem in the Europa Conference League on Thursday ahead of a visit to Everton in the Premier League on Sunday.